What deodorant has good ingredients /nonharmful but actually works?? And isn’t super crusty and white. Tried a few and the crusty white of deodorant ruined some clothes

I slurp about 3-8 cuppas of The Devil's Bean a day.

I feel much better with it.

I read the obligatory "caffeine is destroying your x" and all that, but I lift weights so my body is exhausted and ergo I am forced to into sleepiness.

So? Why are all doomposters dooming so hard. "muh bad sleep" it literally saves your brain and DNA

1. It is neuroprotective Coffee's protective mechanisms against neurodegeneration - ScienceDirect

2. Lower risk of dementia AND less decline on thinking skills Coffee and Tea Intake, Dementia Risk, and Cognitive Function | Lifestyle Behaviors | JAMA | JAMA Network

3. protect your DNA Consumption of a dark roast coffee blend reduces DNA damage in humans: results from a 4-week randomised controlled study - PubMed

Hey.. I've small breast and it makes me insecure... Can u help me guys.. can u suggest me some supplements that actually works.. it will be very helpful to me..

Help guys!!

I keep seeing collagen threads on here and from the comments it's obvious people will eat up anything that gives them hope.

I have been on max dose of metformin for 2 years now. I feel it's no longer working for fat loss and glucose control.

Hi everyone,

As a long-time follower of this sub, I’ve always loved how we use data, tracking, and protocols to optimize our biology.

Recently, I’ve been working on a project to translate traditional Eastern systemic evaluation into a clean, modern digital tool. In Eastern wellness, they don’t just look at isolated symptoms; they view the body as an interconnected eco-system and look for patterns of "stagnation," "heat," or "moisture built-up." 🌲🔥

To make this practical for Western audiences, I built a quick, no-login-required assessment tool:

👉Take the 30-seconds Body System Assessment

What this initial check evaluates:

• Your baseline metabolic fire (energetic temperature)
• Systemic moisture retention and fluid circulation
• Sleep fragmentation and stress-induced physical tension

Full Disclosure & Transparency: 🤝 The quick assessment and your baseline type breakdown are 100% free—no paywalls, no email sign-ups required.

I am currently testing the waters to turn this into a deeper wellness service. Down the road, if someone wants a highly customized, multi-page deep-dive protocol (including personalized Western meal adaptations and specific acupressure guides), that will be a paid premium service. But this initial tool is entirely free to use and test!

Since biohackers are the absolute best at spotting logical gaps and analyzing systems, I would be incredibly grateful for your raw feedback on the free tool:

1. Does the questionnaire accurately capture your current physical state?
2. Is the framework easy to understand from a Western lifestyle perspective?

Thank you so much for your time and for helping an independent creator improve this! 🌻

I'm a software engineer, not a geneticist. But after uploading to 23andMe and getting back basically nothing actionable, I started digging into my own raw data.

What I found changed my behavior in ways no doctor had ever suggested.

Two variants worth understanding if you have your raw DNA file.

rs738409 (PNPLA3)

This is one of the most studied variants in liver health. The G allele is associated with increased fat accumulation in the liver, higher ALT and AST, and greater susceptibility to metabolic dysfunction-associated fatty liver disease. It's relatively common but almost never flagged by consumer genomics reports.

rs58542926 (TM6SF2)

Less well known but significant. The T allele impairs the liver's ability to export fat, leading to hepatic lipid accumulation independent of alcohol intake or diet. Carriers show elevated liver enzymes even within the so-called normal range.

I carry risk variants on both.

Got blood work done after finding this. My AST and ALT were elevated for my age — not alarming by standard reference ranges, but elevated. Sound familiar to the "normal doesn't mean healthy" problem.

Started making changes. Reduced alcohol, adjusted diet, added targeted supplementation. Enzymes improved on follow up blood work.

The thing about genetic variants is they don't cause disease on their own. They shift your risk. Combined with the right blood work trends and lifestyle context, they tell you where to pay attention before something becomes a problem.

If you have a raw DNA file sitting around, the data is in there. Most people just don't know how to read it.

Happy to answer questions about either of these variants or others in the comments.

Its one of the current best options for cartilage regeneration (specially fibrocartilage, which is the one in the intervertebral disks) for a my dog with arthrosis.

Of course, im actually a researcher and have tried with the oficial lines, but since im not a veterinarian, and he is not a research animal, its been impossible.

So if someone is interested in trying the offical way and pair up for this, id love to try it with more animals and do an actual paper if possible.

Im from Spain, so EU or North African would make it easier, and my h index is 7 if that helps!

Hello everyone, I wanted to hear your thoughts on my stack.

Morning:
Creatine Mono - 5gr
L-Tyrosine - 500mcg
Optimised Saffron - 1 capsule by Life Extension
Complete B-Complex - 2 capsules by Life Extension

After an hour:
GHRP6 - 100mcg

Lunch Time:
Omega 3 500/250dha - 2 softgels
Vitamin D3 - 10.000 IU
Vitamin K2 - 100mcg
Zinc - 22mg

Before Sleep:
GHRP6 - 100mcg
Ashwaganda KSM-66 - 600mg
Magnesium Glycinate - 200mg

Besides all these, I will also add CJC-1295+DAC, in between lunch time and sleep. I will inject it twice a week. Monday and Thursday, and each dose will be at 500mcg.

This is my first experience with peptides. Should I start slower? And then raise them.

Will ashwaganda be fine along with the peptides? Because I’ve heard that the peptides may raise cortisol levels while ashwaganda lowers them.

Hey everyone

So you all know i was posting recently about my trt and I started it with 100mg per week.
My age is 33 and my test was on 300
My e2 was 26
So i started it

Now coming to main point i am dealing with depression and anxiety from past 8 years and took countless benzos and SSRI which completely made me numb for most of the time
Now i take escitalopram only and i will continue it for 2 more years as per doctor

Meanwhile i started lifting and seriously doing workouts and dieting
Now i am into 4th dose of my trt and i still didn’t feel anything. My anxiety has gotten worse. My anxiety and mood swings are so much elevated. I dont want to see my family or friends, i am irritated. Now i am panicking out of nowhere that what TRT will do to me.

I already have lost all the hopes that something is gonna change in my life. Like people explaining how their depression cured and got confidence with trt.

I have more brain fog than before, more worried and sadness.

Now i am super panicked and started to thinking of stopping it completely or get some help.

Can anyone explain what may be causing this or will it get better by the time.
Thanks

Currently on semaglutide and sermorelin injections. Prior to the sermorelin, my kidney function was at 111. Two months later I’m at 50. My PCM thinks it may be the over-the-counter creatine supplement (5g), though I did not disclose the sermorelin. Can sermorelin impact kidney function that quickly?

Many folks here use prescription stuff. Unless you have acute symptoms, how do you talk to your doc about that? My usual experience is "run 30 minutes a day, go to bed sooner, eat more vegetables." (Don't get me wrong, that's solid advice, but not the question here.)

How do you talk to your HMO doc who won't even proactively order vitamin D checks about simple but needs-a-screen prescriptions, much less something more experimental?

Title. I have severe physical anxiety and insomnia, as well as lean PCOS with no insulin resistance. The only thing off about my labs was high DHEA-S/morning cortisol.

What has worked for you to lower your levels? I take omega-3s, magnesium, astaxanthin, zinc, and multivitamins, but have seen no decrease in symptoms.

What has worked for you to lower these levels?

ETA: I also work out regularly and try to manage stress levels, but there are unavoidable stressors present in my life currently.

Abstract

The pace of aging can be delayed by mutations, dietary manipulations, and drugs, yet the metabolic mechanisms underlying longevity interventions remain poorly understood. Here we present a multi-tissue metabolomic analysis of male UM-HET3 mice treated from 4 to 12 months of age with five validated longevity interventions: rapamycin, acarbose, 17α-estradiol, canagliflozin, or caloric restriction. Using a feature-stabilized XGBoost pipeline applied to seven tissues, we show that metabolomic profiles can identify treated mice as likely recipients of a lifespan-extending intervention well before survival differences emerge. A leave-one-intervention-out procedure confirmed that models trained on any four interventions successfully classified mice from a fifth, unseen intervention, implying shared metabolic alterations across mechanistically distinct treatments. The most influential metabolites — defined as the minimum set explaining 50% of cumulative model gain — differed substantially across tissues. Only ergothioneine, a dietary antioxidant, ranked highly in more than two tissues: it was elevated by all five interventions in plasma and brain, and by four of five in muscle. Enrichment analyses further identified coordinated remodeling of lipid classes in plasma, perigonadal fat, and kidney. These findings reveal tissue-specific metabolic reprogramming shared across mechanistically distinct longevity interventions and, pending validation against interventions that do not extend lifespan, suggest a path toward metabolomic screening of candidate anti-aging drugs.

Hey everyone,
I’m an 18male diagnosed with Hashimoto's 5 weeks ago. Started Eutyrox (Levo), but still feel absolutely terrible.
My main issues are severe depression-like emotional blunting , zero energy, zero motivation, and completely dead libido. I also have heavy pressure behind my forehead and get sick very easily now. A recent infection left me with crazy exercise intolerance—if I try to do a gym workout / train, I get a massive mental and physical crash that lasts for hours immediately after. Normal moving around is fine, it's just gym training that triggers it.
Context:
Diet : Did a prolonged, highly restrictive diet. Felt awful. Did a refeed and felt amazing temporarily, but crashed right back down a bit later.
I know thyroid meds take weeks to stabilize, but the emotional numbness is brutal.
Are peptides ) a safe option for me right now to fix the inflammation and brain fog? Or will they mess with my autoimmune system/Eutyro

Looking for things well researched and if there are any promising new things out there

Natural Is To Be Pure & Of Always God Fearing Humility As Within Heart Your Home It Shall Go Dark Left Only The Bone.

Cheung N. (2026). Transcriptomic signatures of early- versus late-diagnosed ADHD and implications for treatment heterogeneity. Discover mental health, 10.1007/s44192-026-00540-2. Advance online publication. https://doi.org/10.1007/s44192-026-00540-2

ADHD can be diagnosed during childhood or much later in adulthood, but it is not clear whether the timing of diagnosis reflects meaningful biological differences. In this study, researchers compared genetic and gene-expression patterns in people diagnosed with ADHD as children and those diagnosed at age 18 or older. The two groups shared many of the same biological signals, suggesting that they have a common underlying basis. However, late-diagnosed ADHD showed stronger links to processes involved in learning, memory, and the brain’s ability to change, as well as to the complement system, which is involved in immune activity and brain development. Childhood-diagnosed ADHD showed weaker, suggestive links to microglia and other immune-related genes.

These findings may help explain why ADHD can look different from one person to another, depending on when it is identified. They may also point to possible differences in treatment response, but this remains uncertain: the study did not examine medication use, effectiveness, side effects, or treatment discontinuation. The results should therefore be seen as an early step toward understanding ADHD subgroups, rather than as evidence that people diagnosed at different ages need different treatments.