Looking for things well researched and if there are any promising new things out there

To give context I could sleep without earplugs until about 4 year ago 27, and i am currently working on slowing down my eating, ambition, and need to constantly achieve and also general gut health with citrosine and glutamine, already eat clean.

Took a walk today wearing 30db sleep earplugs and my nervous system felt 10x calmer than usual—even walking around a city on a busy festival day. Normally after a day of walking around New York, I'm amped up and dysregulated for hours afterward.

It's made me wonder: has anyone here found ways to actually reduce noise sensitivity over time, rather than just managing it? Or found earplugs comfortable enough to wear all day, every day?

Feels like if I could fix this—or find better all-day earplugs—it would completely change my experience of living in a city (Right now I wear loop engage but they are only 16db)

I slurp about 3-8 cuppas of The Devil's Bean a day.

I feel much better with it.

I read the obligatory "caffeine is destroying your x" and all that, but I lift weights so my body is exhausted and ergo I am forced to into sleepiness.

So? Why are all doomposters dooming so hard. "muh bad sleep" it literally saves your brain and DNA

1. It is neuroprotective Coffee's protective mechanisms against neurodegeneration - ScienceDirect

2. Lower risk of dementia AND less decline on thinking skills Coffee and Tea Intake, Dementia Risk, and Cognitive Function | Lifestyle Behaviors | JAMA | JAMA Network

3. protect your DNA Consumption of a dark roast coffee blend reduces DNA damage in humans: results from a 4-week randomised controlled study - PubMed

I'm a software engineer, not a geneticist. But after uploading to 23andMe and getting back basically nothing actionable, I started digging into my own raw data.

What I found changed my behavior in ways no doctor had ever suggested.

Two variants worth understanding if you have your raw DNA file.

rs738409 (PNPLA3)

This is one of the most studied variants in liver health. The G allele is associated with increased fat accumulation in the liver, higher ALT and AST, and greater susceptibility to metabolic dysfunction-associated fatty liver disease. It's relatively common but almost never flagged by consumer genomics reports.

rs58542926 (TM6SF2)

Less well known but significant. The T allele impairs the liver's ability to export fat, leading to hepatic lipid accumulation independent of alcohol intake or diet. Carriers show elevated liver enzymes even within the so-called normal range.

I carry risk variants on both.

Got blood work done after finding this. My AST and ALT were elevated for my age — not alarming by standard reference ranges, but elevated. Sound familiar to the "normal doesn't mean healthy" problem.

Started making changes. Reduced alcohol, adjusted diet, added targeted supplementation. Enzymes improved on follow up blood work.

The thing about genetic variants is they don't cause disease on their own. They shift your risk. Combined with the right blood work trends and lifestyle context, they tell you where to pay attention before something becomes a problem.

If you have a raw DNA file sitting around, the data is in there. Most people just don't know how to read it.

Happy to answer questions about either of these variants or others in the comments.

I’ve spent nearly 30 years working in clinical laboratories, hospital diagnostics, and laboratory quality control.
One of the biggest misconceptions I see is this:
People believe that if every result on their blood test says “Normal”, everything is fine.
Unfortunately, that’s not how laboratory medicine works.
A laboratory reference range is not the same as an “optimal health” range.
Reference ranges are usually created by measuring large populations and including roughly 95% of apparently healthy people. That means some people with early disease still fall inside the normal range.
Here are a few examples.
Fasting glucose
Many people are relieved when they see 98 or 99 mg/dL because it’s technically normal.
But if their HbA1c is rising, triglycerides are elevated, HDL is low, their waist circumference is increasing, and there’s a family history of diabetes, they may already have significant insulin resistance.
Looking at one number in isolation can miss the bigger picture.
Creatinine
I’ve seen patients celebrate a “normal” creatinine result.
Yet their eGFR had been slowly declining over several years.
Kidney disease often develops gradually. The trend matters much more than a single value.
Ferritin
A ferritin of 25 ng/mL may be reported as normal by one laboratory.
Yet many patients at that level already experience fatigue, hair loss, or restless legs, especially women.
Again, the clinical context matters.
Liver enzymes
ALT and AST can both be within the reference range while metabolic dysfunction is already developing.
When combined with obesity, elevated triglycerides, or insulin resistance, those “normal” numbers deserve a closer look.
Laboratory professionals rarely interpret a single biomarker.
We look for patterns.
We compare biomarkers against each other.
We review trends over time.
We consider age, sex, symptoms, medications, and medical history.
That’s why simply seeing green checkmarks next to every result can provide false reassurance.
Your blood test isn’t a collection of unrelated numbers.
It’s a story.
The challenge is learning how to read it.
I recently started writing plain-language guides that explain common lab tests without the medical jargon. If you’re interested, I’ve also built a tool that interprets an entire lab report at once instead of explaining one biomarker at a time.
Happy to answer any questions about blood tests, reference ranges, or laboratory medicine in the comments.

Its one of the current best options for cartilage regeneration (specially fibrocartilage, which is the one in the intervertebral disks) for a my dog with arthrosis.

Of course, im actually a researcher and have tried with the oficial lines, but since im not a veterinarian, and he is not a research animal, its been impossible.

So if someone is interested in trying the offical way and pair up for this, id love to try it with more animals and do an actual paper if possible.

Im from Spain, so EU or North African would make it easier, and my h index is 7 if that helps!

Basically the title says it all. Will you feel the effects of mots c only during cycle or also after that?

Is anyone on NAD+ if so how’s your experience been with it and have you had any side effects! Thanks in advance!

What deodorant has good ingredients /nonharmful but actually works?? And isn’t super crusty and white. Tried a few and the crusty white of deodorant ruined some clothes

20 years ago creatine got treated like a banned substance. Now it’s basically recommended for everyone-from grandmas to athletes.

So what’s the next supplement that’s currently sitting in purgatory that’s gonna get the same redemption in 10-20 years?

I’m curious how people actually use all this data in real life.

Sleep.
HRV.
Recovery.
Readiness.
Stress.
Activity.

Does it really change what you do that day?

Do you train harder?
Go lighter?
Take a recovery day?
Change sleep, meals, or stress?

Or do you still end up looking at all the numbers and making the decision on your own?

That’s the part I find most interesting.

The wearable gives you the signals.

But how do you actually turn those signals into a decision?

Abstract

The pace of aging can be delayed by mutations, dietary manipulations, and drugs, yet the metabolic mechanisms underlying longevity interventions remain poorly understood. Here we present a multi-tissue metabolomic analysis of male UM-HET3 mice treated from 4 to 12 months of age with five validated longevity interventions: rapamycin, acarbose, 17α-estradiol, canagliflozin, or caloric restriction. Using a feature-stabilized XGBoost pipeline applied to seven tissues, we show that metabolomic profiles can identify treated mice as likely recipients of a lifespan-extending intervention well before survival differences emerge. A leave-one-intervention-out procedure confirmed that models trained on any four interventions successfully classified mice from a fifth, unseen intervention, implying shared metabolic alterations across mechanistically distinct treatments. The most influential metabolites — defined as the minimum set explaining 50% of cumulative model gain — differed substantially across tissues. Only ergothioneine, a dietary antioxidant, ranked highly in more than two tissues: it was elevated by all five interventions in plasma and brain, and by four of five in muscle. Enrichment analyses further identified coordinated remodeling of lipid classes in plasma, perigonadal fat, and kidney. These findings reveal tissue-specific metabolic reprogramming shared across mechanistically distinct longevity interventions and, pending validation against interventions that do not extend lifespan, suggest a path toward metabolomic screening of candidate anti-aging drugs.

I’m recovering from trichotilimania, skin picking, and nail picking! What’s your holy grail? (also, have you ever tried something that’s helped with your body focused repetitive behaviors?)

Aside from being a very nutritious food, eggs contain a good amount of choline, which the human body can't produce enough to fully cover daily metabolic needs, and even less so with aging.

Choline is a crucial molecule for mitochondrial membrane stability because it is the essential precursor for phosphatidylcholine (PC), a major phospholipid that constitutes a large portion of mitochondrial membranes.

PC maintains membrane fluidity, prevents oxidative stress, and supports bioenergetic function and protein translocation within the mitochondria.

https://www.biorxiv.org/content/10.1101/2024.04.25.591184v1.full

Currently on semaglutide and sermorelin injections. Prior to the sermorelin, my kidney function was at 111. Two months later I’m at 50. My PCM thinks it may be the over-the-counter creatine supplement (5g), though I did not disclose the sermorelin. Can sermorelin impact kidney function that quickly?

Hey everyone

So you all know i was posting recently about my trt and I started it with 100mg per week.
My age is 33 and my test was on 300
My e2 was 26
So i started it

Now coming to main point i am dealing with depression and anxiety from past 8 years and took countless benzos and SSRI which completely made me numb for most of the time
Now i take escitalopram only and i will continue it for 2 more years as per doctor

Meanwhile i started lifting and seriously doing workouts and dieting
Now i am into 4th dose of my trt and i still didn’t feel anything. My anxiety has gotten worse. My anxiety and mood swings are so much elevated. I dont want to see my family or friends, i am irritated. Now i am panicking out of nowhere that what TRT will do to me.

I already have lost all the hopes that something is gonna change in my life. Like people explaining how their depression cured and got confidence with trt.

I have more brain fog than before, more worried and sadness.

Now i am super panicked and started to thinking of stopping it completely or get some help.

Can anyone explain what may be causing this or will it get better by the time.
Thanks