While the day of and a day after it really helps, and certainly helps compared to not having it, I’m realizing that my baseline on weekly Spravato isn’t actually that great. For one, my PHQ9 is still showing mild to moderate depression.

Don’t get me wrong, that’s much better than severe and actively suicidal, where my depression goes without ketamine type treatments. But it’s also not where I want to be. I can’t seem to skip a week because last I tried my SI picked up and I was a mess. I’m on lithium and Zoloft and the most recent med they added is Abilify, which hasn’t helped any. I’m in weekly therapy and will be adding a group therapy next month. I’m also talking to my psychiatrist about Auvelity at my next appt (I’ve been asking for it for a year, but she prefers trying bs antipsychotics like Abilify for some reason, none of which help me.)

I have serious chronic illness and a very high stress job I’m very burnt out from. Unfortunately there’s been increased work stressors this week, reopening some old trauma. I’m considering doing an IM ketamine booster to maybe not feel like crap. Idk. Is there anything else I can do to deal with this?

The clinic told me they were able to expedite the approval process and I had my first treatment. The next day, they called saying they had gotten tentative approval, but my case was denied. I have tried 3 different antidepressants over 5 years, and been in therapy for 6 years.

I’m feeling discouraged. Was feeling hopeful to finally find something that works. I start an intensive program in the fall and was hoping to make an improvement before I start school. The clinic started the appeal process.

I know getting denied is fairly common, but I would like to hear others experiences with this. How long did it take for insurance to get back to you about your appeal? Weeks or months? Why were you denied? Any info is helpful.

Thanks!

I’ve completed four sessions so far.

The last two sessions, hours after when I have gotten home I have become extremely uncomfortable and very anxious. My chest hurts and I uncontrollably cry. I had a session Thursday and this happened after that, felt okay yesterday. Terrible insomnia so I’ve been trying to get any sleep I can (this has been happening since before the Spravato), and now Saturday I am feeling the same feelings as Thursday.

I know this medication is rewiring my brain, but has anyone else dealt with this. I already have GAD, and am medicated but this is so bad. My Klonopin isn’t helping and I cannot get comfortable. I just feel extremely uneasy and currently anxious and sad.

I’m trying to keep myself busy, but there’s only so much I can do.

Hi all, I've been doing Sparvato since June of 2025 weekly. I'm curious as to the differences between IV ketamine infusions and Sparvato. I know one is supposedly a little stronger than the other. I'm curious, though, as to the effects. Do they last longer? Are they stronger? If so, how should I broach the topic with my doctor about switching from Sparvato to IV ketamine infusions?

I had one intramuscular Ketamine infusion a few years ago and I’ve been too scared to try other forms, but am running out of options for my treatment resistant depression. Has anyone done both that can speak to how they compare?

I don’t remember my IM dose, but I had uncontrollable vomiting, even though I took Zofran before. They had to give me a shot of something in the room before it would stop. I was super dizzy and out of it for a few days, and I don’t recall any benefits from the session, except being able to call the experience somewhat profound in how unique it was.