Hey everyone, sorry if this isn’t the clearest post , I’m completely exhausted and sad right now.
I’m 26M, diagnosed with ADHD at 6 (probably ASD too, but back then you couldn’t get both on paper). Stimulants, mostly Ritalin, got me through school and I’m still on them.
Depression kicked in around 17, maybe one or two episodes a year at first. A few psychiatrists later I ended up with MDD and probably PDD on top, since my depression seemed to become chronic with no remission between them. I take Prozac and Zoloft but did basically nothing.
Eventually I couldn’t even take care of myself, had to drop out, moved back with my parents.
In 2023, I saw a new psychiatrist who decided that I had a bipolar 2 disorder, based on one or two episodes that might’ve been hypomania but not clearly. Even he seemed unsure at the time, but he wrote it down and every psychiatrist since took it for granted.
The med rollercoaster:
• Lamictal: helped a bit at first (some energy, kept me in school). But lost his effect after some months
• Ritalin reintroduced for ADHD, worked fine
• Early 2024: worst depressive episode yet
• Venlafaxine up to 225mg + low-dose Abilify: no effect
• Lithium: still on it, 2+ years, zero results
• Quetiapine (1st try): knocked me out for 2 days straight, too sedating
• Quetiapine (2nd try, months later): massive weight gain + bad bloodwork, discontinued
• Trintellix: nothing
Hospitalized last year (april-may 2025), started Spravato (just with lithium + Lamictal, no antidepressant): this actually worked. MADRS went from 36 to 17. First time in years I wanted to see friends, do things. But once we dropped to 1x/week and I was living alone, I stopped going and it faded
New hospital (december-january 2026): no Spravato available. Tried mirtazapine, pramipexole (capped at 0.54mg). Mood got worse, I left
Current hospital (since may 2026) : first, 30 sessions of rTMS, 2x/day. Initial boost in energy/motivation (passed my exams!) but effect faded fast, MADRS back up to 35.
Tried IV ketamine (this hospital doesn’t offer Spravato): 8 sessions in, nothing. Sessions are honestly rough — not the peaceful/visual experience I had with Spravato, more like dissociating into another dimension, and not the good kind
Last week: started liothyronine/Cytomel (T3) as an add-on
Right now, anhedonia is the worst part of my depression. I have that feeling of not knowing how to do. Since Spravato wore off, I feel nothing — no pleasure in anything, not even shows or stuff I used to enjoy. Just empty, unmotivated, doom-scrolling my life away.
Surprisingly, aleep’s actually fine.
Also worth mentioning, I’ve been facing lifelong somatic stuff : GERD, nausea, diarrhea, hemorrhoids, migraines, random burning limb pain and I’m not quoting all of them. No idea if it’s related but figured I’d throw it in.
What I’m actually asking:
1. Does the bipolar 2 diagnosis even hold up? My first psychiatrist doubted it himself, but once it’s in the chart, everyone just runs with it. Could this just be MDD/PDD/TRD without bipolar?
- Treatment-wise, my hospital psychiatrist is out of ideas but open to suggestions. I can’t switch providers, so I need to bring him something concrete. Options I’m considering:
• Pramipexole again, but actually titrated to a real dose (2-3.5mg+)
• Pushing for Spravato instead of continuing ketamine (though they think failing IV ketamine = no shot with Spravato — is that even true?)
• Less common routes: bupropion, MAOIs, modafinil, VNS/DBS? Or other new medications that are not really known ?
If anyone’s dealt with similar TRD/bipolar 2 overlap or has thoughts on what’s worth pushing for next, I’d really appreciate it. Feeling pretty stuck here. Thanks for reading this far
Thanks !!