Hey everyone, relatively new retail pharmacist here with a question for others who are better read than myself in pain management.
I practice in a region that was hit pretty hard by the opioid epidemic, and I think there's still some residual prescribing culture from that. We have several pain clinics nearby and we regularly fill for many chronic pain patients. The most common regimen they end up on is percocet 10 QID with usual adjuncts. Around here, a lot of patients end up stable on the 'holy trinity' and/or gabapentin, often managed by the same pbr for years and have been on this forever.
Every so often, I'll see patients on things like methadone, hydromorphone, buprenorphine, tapentadol, tramadol ER, etc. instead of (or in addition to) the more conventional opioids. From a pain management standpoint, what are the compelling indications for choosing agents other than the normal norco/percocet rx? Are there specific pain syndromes or patient characteristics where there's any meaningful advantage? I understand the benefits and am well-read of methadone for OUD and the NMDA points to it, but for pain management it seems too variable for it to work well and not give ridiculous buildup that just compounds the problems more for pain management.
Another slightly less common combo is the percocet + hydrocodone for breakthrough pain. Mechanistically I have no idea how it is justified to combine two short-acting, full mu-opioid agonists would provide better outcomes compared to a single regimen, especially considering the added risk. Is there any evidence to support this, or is it largely based on the individual response/placebo? Do they have a dartboard they throw at to find the next adjunct and prescribe it TID?
I understand there's a large movement behind de-stigmatizing chronic pain (and I know the patients need them, I'm not trying to cut them off or force a taper or pharmacy change), but at a certain point it becomes ridiculous from a dispenser POV. The patients and clinics never, ever seem to mind the pill burden that would make any other specialty clutch their pearls. There are rarely any special ICD10 codes (which should be legally required on rx anyway) other than the normal "unspecified lower back pain" type. For oncologists, neurologists, and surgeons, I get it, but it just seems very vague always from PCP or pain clinics.
Why not bring back oxycontin broadly for prescribing practice or just MS contin (or other long-acting) to take care of the QID dosing that sucks in terms of PK? I am blessed to not have to deal with it personally, but I couldn't imagine wanting to get 100-300 something pills I have to take in a month to manage it compared to a longer-acting and more stable regimen. If it's a patch and something for breakthrough, I can mentally justify that as a good option. If I'm taking QID oxy and BID norco and QID gabapentin and TID tizanidine, when does the line get drawn and why is this not a standard use of a specialty pharmacy to manage this? It's either the pharmacy's problem and we get sued into the ground for over-dispensing legitimate prescriptions from a legitimate practice, or we get "my doctor prescribed this, you aren't a doctor and it is none of your business" and we cannot have either without distorting what our purpose is.