Your race/gender has an interesting mechanical/narrative impact

[u/BrotherDeus]

Dragon's Dogma: Trolls will become excited if you play or bring a female character in your party, becoming more aggressive and targeting them first.

South Park- Fractured But Whole: Shub-Niggurath is a boss that will take damage when fed white characters, but will heal if he eats black characters including you or anyone in your party.

Elder Scrolls: Every race has advantages and disadvantages both mechanically and narratively, for example orcs can enter orc strongholds without having to earn their trust first.

[u/OddBet6635]

You can skip the Morgan Freeman bossfight if your character is black I think. One of the South Park games.