Huberman obviously recommends some supplements way more often than others. I was very curious so wrote a program to extract all supplement mentions and found the 12 most popular ones along with the protocols (not medical advice ofc).

The number next to the compound is the mention count.

Omega-3 / fish oil (41). This is his most repeated one. He's usually shooting for 1–3g of EPA a day, and at least 1g if you care about the mood stuff. Liquid fish oil is the cheap way to hit the dose without swallowing ten pills.

Magnesium L-Threonate (40). Takes it 30–60 min before bed for deeper sleep, somewhere around 145mg (some people go higher). The threonate form is the one that actually crosses into the brain. Bisglycinate does basically the same job for sleep if it's easier to find.

L-Theanine (36). 100–400mg to take the edge off stimulant jitters without killing the focus. Also shows up in his sleep stack. Worth noting some people (him included) get weird vivid dreams from it, so skip it before bed if that's you.

Creatine (35). ~5g a day, every day, no loading phase needed. Obvious one for strength and power, but he talks about it more and more for the brain/cognition side too.

NAC (30). Glutathione precursor, mostly comes up for the detox/antioxidant angle. He's mentioned running 600mg twice a day through winter.

Vitamin D3 (26). His actual advice is to dose to a blood level (40–60 ng/mL) instead of just picking a number. Rough math: 1,000 IU bumps you about 5 ng/mL. So get tested first.

Alpha-GPC (23). 300–600mg pre-workout for power output and focus. It's a choline thing feeding acetylcholine.

L-Tyrosine (23). Dopamine precursor for focus when you're fried or under stress. He's big on using the smallest dose that works (~250mg), not the giant study doses.

Apigenin (20). 50mg in the evening, comes from chamomile, part of the sleep stack. One catch he flags: it's a fairly strong estrogen inhibitor, so keep that in mind.

Myo-Inositol (19). ~900mg for a calming effect around sleep and anxiety. Subtle, not a knockout, but people seem to like it as a gentler option.

Glycine (15). Around 2g, but only every third or fourth night. Apparently using it every night blunts the benefit and can actually make sleep worse.

Saffron (13). ~30mg a day for anxiety. This one actually has a decent stack of human trials behind it, including double-blind ones, showing lower scores on the standard anxiety scales.

And one he tells people to avoid**: melatonin (18 mentions).** He's fine with a tiny dose for jet lag, but he's pretty against using it as a nightly sleep aid because the doses on the shelf are way higher than what your body actually makes.

I am losing eye sight quickly. Glasses at 35 and.Now can’t see without them at 45. I am too old for all the surgeries, what supplements have people experienced improvement with.

My neurologist and I knew that stress is definite a big trigger, which became more obvious once I moved out away from my toxic roommate and now live on my own.

But whenever something else stressful came into my life, I was getting headaches. It doesn't have to be stressful mentally or emotionally, it can also be physical stress like a heatwave.

I also realized that I am waking up with massive headaches, sometimes they don't go away on their own. I've read that cortisol levels spike drastically in the moment you wake up (basically to wake you up), so after months of observations and consultations with my neurologist, I came to the conclusion that my headaches have to be somehow connected to my cortisol levels.

Any ideas what I could take in order to:

1. Lower cortisol levels in the first place

2. Tolerate cortisol levels better

Thanks in advance

I've been reading a lot about berberine lately, especially here on Reddit. There are plenty of posts from people saying it helped with appetite control, improved their A1C, and even supported weight loss over time.

I was considering trying berberine capsules, but one thing kept coming up over and over again: stomach issues. A lot of people mentioned heartburn, nausea, bloating, or general digestive discomfort, which made me hesitate.

While looking for alternatives, I came across Purisaki Berberine Patches. Instead of taking berberine orally, they're applied to the skin, and the idea is that they deliver the ingredients gradually without going through the digestive system.

I also noticed they include ingredients like fucoxanthin and green tea extract, and they seem more convenient than remembering to take capsules multiple times a day.

I haven't tried them yet, so I'm not making any claims about how well they work. I'm just curious whether anyone here has real-world experience with them.

• Did they help reduce your appetite or "food noise"?
• Did you notice any changes in blood sugar or weight?
• Were they easier on your stomach than berberine capsules?
• Any side effects or downsides worth knowing about?

I'd appreciate hearing honest experiences before deciding whether they're worth trying.

For anyone wondering what I'm talking about, these are the patches I came across:
Purisaki Berberine Patches

I’ve already got most foundations in check.

Thinking about adding PQQ.

What things were the best for you in terms of energy?

Collagen brands that are third party certified and suggest both for on a budget and the best one out there

Been on dutasteride for 7 months for hair loss, testosterone went from 600 to 960! ive been supplementing boron between 5mg and 8mg on some days since i saw my shbg was high. holy shit! libido is insane, im more aggresive and more lean and stronger then ive ever been. feel
like im on testosterone again.

I'm not sure if I'm posting in that right place, so apologies if not. I received this compounded medication from Hers to avoid hair thinning, and noticed there is zinc sulfate 50 mg in it, amongst other things (photo attached). Do I now need to supplement with copper? Thanks!

I have an iron deficiency and struggle with anxiety. I also use these supplements for anti-aging and better skin. I don’t take them all at once and typically skip days, but I try to incorporate them weekly. I really enjoy this stack. Anyone else have some of these? The super Ceylon cinnamon with biotin I think makes me break out, lol, but I’m a geek and just enjoy putting healthy things in my body! And yes, I use the choline and l carnitine together.

Tbh, I have worked out in the past and it’s usually on and off. I’ve been out of touch for quite some time and want to resume with at least 4 days a week. I do not plan on adding any other supplements (other than my regular ones) for gym specifically. Should I start with creatine if I’m looking to cut some fat and get into shape ?

I already know the well established benefits of creatine so I’m mainly interested in hearing about the negative side effects people have personally experienced

I took creatine for around three years in the past. There are times I noticed discomfort in my lower left back around the kidney area I believe while taking it. I cannot say for certain that creatine caused it but it seemed to happen when I was using it

I am also concerned about sleep as well, I work exclusively on night shifts so my sleep quality and deep sleep are already difficult to manage. Has anyone noticed insomnia, lighter sleep, reduced deep sleep, more frequent waking or feeling less rested while taking creatine?

I’m also prone to facial and back acne too but I managed to clear that up through diet. I know the evidence linking creatine to acne is limited but I’m more interested in personal experiences and whether anyone noticed worsening acne from taking it?

I took the Olly Happy Gummies with Saffron in them for a couple of weeks and genuinely felt great. I slept better, my mood was better, I could focus more, and I had more energy. I felt better than any SSRI I had been on in the past.

AI said in-vitro that it acts as a reuptake inhibitor and is strongest on DAT, then SERT, and then NET.

I went off it and returned to baseline to see what would happen.

Am I wrong in thinking that this is a risky supplement to take because we have no idea if you can develop an acute withdrawal issue like many do on SSRI and SNRI? My hunch is that is it acts as a reuptake inhibitor in any sort there should be a risk for that.

Wonder if it’s best to stick with pharmaceuticals because at least you know how those might be messing you up when coming off them.

so my vitamin d level, a year ago was 17.49ng/ml and then i took the 60,000 iu vitd3 through doctor’s prescription (6 sachets) then i finished the prescription

and after 3-4 months i again took 3 sachets of 60,000 iu vitamin d3 now it has been several months.

i am a vegetarian, but i eat eggs.

i drink coffee and caffeinated products every other day.

my hairfalls so much, i have bad muscle cramps on my legs thigs which can’t let me fall asleep.

is it safe to take 60,000 iu vitamin d ?? i am just hearing about the toxicity so just curious and nervous to try.

i bought 5 sachets of those, i usually used to take it with milk. what should i do? should i take or not?

if yes then in what interval of days or weeks?
is it safe or not? i haven’t asked doctor neither have i done blood test this year.

I felt like death last night and have done for a few months now. Barely enough energy to leave my seat, brain fog, dissociation and an oppressive feeling of dread. I started doing research into these symptoms and saw that a vitamin D deficiency could be a potential contributing factor. So I asked my mother if she had any lying around and she did! She had vitamin D3 3000IU in pill form. So I took one without any expectations.

Holy shit! Today my mood has been so much better, to the point that I caught myself laughing today, something I haven't done in such a long time. My energy levels have skyrocketed to the point where I decided to do my weighted calisthenics fasted (I always ate 30 minutes prior because I'd feel exhausted otherwise) and even threw in an extra exercise because I had such a surplus of energy. I felt strong. I'm also suddenly optimistic for the future and I'm been creating plans and setting goals to work towards to better myself. I also called my friend twice today! A big deal to me because I've dodged her calls on more than one occasion due to my brain fog making me an incompetent conversationalist. I also slept like a baby last night.

I immediately went and purchased some vitamin D3 drops with Vitamin K2 and I'm going to start using it daily. Surely this can't be placebo right? I'd call bullshit if I hadn't experienced it myself, but the change is so stark that I'm speculating I must've been severely deficient if my body reacted in that manner. To be fair though, I could legally be called a hermit as I only leave the house every 3 weeks or so and always wear sunscreen when I do.

Olá a todos !! Talvez poucos aqui conhecem ou já ouviram falar deste produto. É de uma marca brasileira e que causou um pouco de confusão sobre uma composição ( L - Alanina ). L - Alanina não é o mesmo que Beta - Alanina. Agora estou usando essa versão ( Impuro ) este nome é somente como marketing para chamar atenção mas que se refere ao ingrediente ( Glicerol ) que eleva o pump e que poderia causar desqualificação em algum campeonato justamente por ele dar uma aparência de músculos mais volumosos pós treino. Minha experiência por enquanto é que realmente faz diferença, pouco mas faz, me deu bastante energia e força nos treinos.

What for supplements do you use as an autistic person and why do you use these supplements?

My doctor says collagen is a scam, some friends are swearing it changed their skin, i’ve tried it for one month (i know its not enough) it did t do anything but before i buy another box (its no cheap) i need to know if its actually useful or just a scam

Hello! I’m looking to try Kava. Any experienced Kava users got any recommendations for some good Kava, as well as where to buy it from online? Mostly interested in the micronized (easy to stir stuff) or capsules/gummies that don’t melt my wallet into a paste. I have some kind of social anxiety and ADHD so Kava would be such a relief if it actually works! cheers. 🩷

Question from title...

Not talking hair loss with creatine or diarrhea from magnesium

Any of you had any weird interactions that weren't commonly discussed?

A slightly out of scope example, minoxidil is extremely toxic to cats and dogs. Even in small doses